In the NFL, there is no such thing as a "lock" when it comes to betting on games.
Case: New England loses to Arizona in their home opener
Point: New England is a double-digit favorite and isn't supposed to lose a home opener
So when choosing your NFL Betting slate, make sure you're prepared. Injury reports, as illegal as I think they should be, help out immensely. I don't play football, but I'm guessing that players see other players injury reports and may try targeting said areas? Just saying.
Either way, this season has seemed a little mystifying when it comes to picking games. I'll take a look at the games in Week 3.
Philadelphia (-3.5) at Arizona - This is an Arizona team that is 2-0 - as is Philadelphia - and coming off an emotional west-to-east win over the Patriots in a game no one really gave them a chance in. Bettors be damned. I like the Cardinals +3.5, thanks. They're hot dating back to last season and Vick looks pretty human thus far.
Atlanta at San Diego (-3) - Atlanta is 2-0 and has a high-flying offense and two stud receivers in Roddy White and Julio Jones. And a star QB in Matt Ryan and a big name RB in Michael Turner. San Diego is also 2-0, although you wouldn't know because they really only have one or two "names" - Philip Rivers and Antonio Gates. I understand it's east-to-west, but the Falcons are the real deal. That being said, I would put my money - if I had any - on the Bolts at home laying the three points.
So again, when choosing games to take action on, do your homework. And check out a solid betting site at NFL Betting.